The micro/tiny form factor PCs generally only have space for a 2.5" drive, while the SFF/desktop size PCs can fit at least one 3.5" drive.

Dell, 8th Gen Intel with one 3.5" drive bay: https://www.dell.com/support/manuals/en-us/optiplex-7060-sff/opti_7060_sff_setup_specs_manual/storage?guid=guid-4eab9a0b-c403-4bcd-b692-9419bddfed24&lang=en-us

Lenovo, should have one 3.5" drive bay: https://www.lenovo.com/us/en/p/desktops/thinkcentre/m-series-sff/thinkcentre-m920s/11tc1mdm92s?orgRef=https%253A%252F%252Fwww.google.com%252F&srsltid=AfmBOorJ_EUW-QYIIIGy3i7ZJbitPq8UWoxdoQxtM_BNabrKcNojn7WL#tech_specs

The article may be a bit off on the AMD processors, K10 (Phenom etc) supports SSE4a and was released in late 2007.

Here’s one for the Genesis/Mega Drive: https://segaretro.org/Wacky_Worlds